Research
Research Group
Research Facilities
Biomaterials Testing Research Center
Histological service; automated tissue processing, sectioning, Immunocytochemistry and special staining
Center of Molecular Genetics in Dentistry
Microarray Facilities, Bioanalyzer, Molecular tools
Research Theme
Oral Cancer Biology
Selected Publications
- The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity. J Oral Pathol Med. 2016 Sep;45(8):581-5.
- Inflammation related genes are upregulated in surgical margins of advanced stage oral squamous cell carcinoma. J Oral Biol Craniofac Res. 2017 Sep-Dec;7(3):193-197.
- Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. Arch Oral Biol. 2017 Feb;74:69-74.
- Expression and influence of Notch signaling in oral squamous cell carcinoma. J Oral Sci. 2016;58(2):283-94.
Dental Pulp, Periodontal Ligament and Bone Biology
Selected Publications
- Intermittent compressive force promotes osteogenic differentiation in human periodontal ligament cells by regulating the transforming growth factor-β pathway. Cell Death Dis. 2019 Oct 7;10(10):761.
- Gene expression profiling of Jagged1-treated human periodontal ligament cells. Oral Dis. 2019 May;25(4):1203-1213.
- Interleukin-1β induces human cementoblasts to support osteoclastogenesis. Int J Oral Sci. 2017 Dec 13;9(12):e5.
- MiR-302a-3p Regulates RANKL Expression in Human Mandibular Osteoblast-like Cells. J Cell Biochem. 2017 Oct 23. doi: 10.1002/jcb.26456. [Epub ahead of print]
- Histone deacetylases and their roles in mineralized tissue regeneration. Bone Rep. 2017 Aug 16;7:33-40.
- Biphasic Effect of ATP on In Vitro Mineralization of Dental Pulp Cells. J Cell Biochem. 2018 Jan;119(1):488-498.
- Purinergic 2X7 receptor activation regulates WNT signaling in human mandibular-derived osteoblasts. Arch Oral Biol. 2017 Sep;81:167-174.
- The effect of iloprost on cell proliferation and angiogenesis-related gene expression in human periodontal ligament cells. Odontology. 2018 Jan;106(1):11-18.
- Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. Bone. 2017 Feb;95:76-84.
Dental Stem Cell Biology
Selected Publications
- Notch signaling partly regulates the osteogenic differentiation of retinoic acid-treated murine induced pluripotent stem cells. J Oral Sci. 2017;59(3):405-413.
- Cobalt Chloride Enhances the Stemness of Human Dental Pulp Cells. J Endod. 2017 May;43(5):760-765.
- Basic Fibroblast Growth Factor Regulates REX1 Expression Via IL-6 In Stem Cells Isolated From Human Exfoliated Deciduous Teeth. J Cell Biochem. 2017 Jun;118(6):1480-1488.
- Comparison of stem cell behaviors between indigenous high and low-CD24 percentage expressing cells of stem cells from apical papilla (SCAPs). Tissue Cell. 2016 Oct;48(5):397-406.
Tissue Engineering
Selected Publications
- Autologous platelet-rich fibrin stimulates canine periodontal regeneration. Sci Rep. 2020 Feb 5;10(1):1850.
- Preparation and characterization of Jagged1-bound fibrinogen-based microspheres and their cytotoxicity against human dental pulp cells. J Biomater Appl. 2020 Mar;34(8):1105-1113.
- Mesenchymal stem cell-based bone tissue engineering for veterinary practice. Heliyon. 2019 Nov 27;5(11):e02808.
- Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells. Sci Rep. 2017 Dec 11;7(1):17358.
- Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells. Sci Rep. 2017 Aug 31;7(1):10124.
Oral Microbiology and Immunology
Selected Publications
- Wss1 homolog from Candida albicans and its role in DNA-protein crosslink tolerance. Mol Microbiol. 2020 Apr 17. doi: 10.1111/mmi.14518.
- Antibacterial property of chitosan against E. faecalis standard strain and clinical isolates. Dent Mater J. 2020 Feb 7. doi: 10.4012/dmj.2018-343.
- Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin. J Prosthet Dent. 2020 Jan;123(1):181.e1-181.e7.
- CdtC-induced processing of membrane-bound CdtA is a crucial step in Aggregatibacter actinomycetemcomitans CDT holotoxin formation. Infect Immun. 2017 Dec 11. pii: IAI.00731-17. doi: 10.1128/IAI.00731-17. [Epub ahead of print]
- Silver diamine fluoride remineralized artificial incipient caries in permanent teeth after bacterial pH-cycling in-vitro. J Dent. 2017 Sep 14. pii: S0300-5712(17)30219-1. doi: 10.1016/j.jdent.2017.09.005. [Epub ahead of print]
- Interleukin-12 modulates the immunomodulatory properties of human periodontal ligament cells. J Periodontal Res. 2017 Jun;52(3):546-555.
Biomechanic and Mechanobiology
Selected Publications
- Intermittent compressive force induces human mandibular-derived osteoblast differentiation via WNT/β-catenin signaling. J Cell Biochem. 2017 Nov 16. doi: 10.1002/jcb.26519. [Epub ahead of print]
- Intermittent compressive stress regulates Notch target gene expression via transforming growth factor-β signaling in murine pre-osteoblast cell line. Arch Oral Biol. 2017 Oct;82:47-54.
- Notch Signaling Participates in TGF-β-Induced SOST Expression Under Intermittent Compressive Stress. J Cell Physiol. 2017 Aug;232(8):2221-2230.
Craniofacial Development and Genetics
Selected Publications
- A novel PITX2 mutation in non-syndromic oro-dental anomalies. Oral Dis. 2017 Nov 9. doi: 10.1111/odi.12804. [Epub ahead of print]
- Dental Properties, Ultrastructure, and Pulp Cells Associated With a Novel DSPP Mutation. Oral Dis. 2017 Nov 8. doi: 10.1111/odi.12801. [Epub ahead of print]
- Monoallelic FGFR3 and Biallelic ALPL mutations in a Thai girl with hypochondroplasia and hypophosphatasia. Am J Med Genet A. 2017 Oct;173(10):2747-2752.
- A novel GJA1 mutation in oculodentodigital dysplasia with extensive loss of enamel. Oral Dis. 2017 Sep;23(6):795-800.
Herbal and Traditional Medicine in Dentistry
Selected Publications
- Asiaticoside induces type I collagen synthesis and osteogenic differentiation in human periodontal ligament cells. Phytother Res. 2013 Mar;27(3):457-62.